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The synthesis of cytochrome P-450 (phenobarbital inducible) and cytochrome P-448 (3-methylcholanthrene inducible) have been studied in rat liver in vivo and in the wheat germ cell. Article Title: Synthesis of Metabolites of Phenobarbital and Mephobarbital: Publication: Organic Preparations and Procedures International: Type: Journal Article. The effect of alcohol in addition with respectively phenobarbital and pyrazole on the heme and porphyrin synthesis in the liver of male rats was studied. protein) prevents the efflux of bilirubin back into plasma bilirubin back into plasma • • Ligandin Ligandin synthesis is induced by Phenobarbital synthesis is induced by Phenobarbital.